Think more clearly through complex clinical cases.
EmpiricalDx helps clinicians expand differential diagnoses, surface overlooked possibilities, and identify next investigative steps when cases do not fit expected patterns.
Clinical reasoning support tool. Not a diagnostic system.
How it works
A worked example
A short case in, structured reasoning out. The goal is to widen the differential, not to replace your judgment.
Sample case
62-year-old man with widely metastatic adenocarcinoma. Rapid progression over six weeks, predominantly liver and bone lesions. PSA only mildly elevated, disproportionately low for the disease burden. Prior workup assumed a prostate primary.
Example analysis
- Top differential
- Poorly differentiated or neuroendocrine-differentiated prostate carcinoma. A PSA that is low relative to extensive bone and visceral disease is atypical for conventional prostate adenocarcinoma and warrants reconsidering the histology.
- What may be underweighted
- Treatment-emergent neuroendocrine differentiation, particularly following androgen-pathway therapy. A non-prostate primary — upper GI or pancreaticobiliary — presenting with liver-dominant metastases.
- Next investigations
- Biopsy of an accessible liver lesion with neuroendocrine markers (synaptophysin, chromogranin A). Serum chromogranin A and NSE. Re-read cross-sectional imaging for a visceral primary, comparing PSMA and FDG-PET avidity.
Clinical focus
A different question
EmpiricalDx is not a search engine or a guideline. It is a reasoning layer for the patient in front of you.
OpenEvidence
What does the literature say?
Clinical guidelines
What is standard care?
EmpiricalDx
What might I be missing in this patient?
Security
Built for clinical data
No patient identifiers
Cases are entered as de-identified clinical summaries. There is no need to submit names, dates, or record numbers.
Not used to train external models
Case content is not sold and is not used to train third-party foundation models.
Encrypted end to end
Data is encrypted in transit and at rest, with access scoped to the clinician who entered it.